Ralph Guenthner was born in Stuttgart. He studied from 1986 to 1992 at the „Hochschule für Darstellende Kunst und Musik“ in Stuttgart with Prof. Enrique Santiago and later on string quartet in the master class of the „Melos Quartett“. In 1992 he began further studies in the master class of Prof. Hermann Voss.
He became a section leader in the Thuringia Philharmonic Orchestra in Suhl in 1993 and three years later in the Brandenburg Philharmonic Orchestra Potsdam. There together with other section leaders of the orchestra in 1997 he founded the Persius Ensemble, a classical nonet. Finally in 2001 he founded the Kammerakademie Potsdam which is the chamber orchestra of the capital city of Brandenburg region.